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Home Topics Infectious Diseases Infections A-Z Lyme borreliosis / Lyme disease Guidelines ›  Lyme borreliosis: Guidelines for Health Professionals

Lyme borreliosis: Guidelines for Health Professionals

  • May 2011. The epidemiology, prevention, investigation and treatment of Lyme borreliosis in United Kingdom patients - A position statement by the British Infection Association. British Infection Association Position Statement on Lyme Disease (PDF, 208 KB)  [This PDF is made available by kind permission of the publisher, Elsevier]
  • May 2010 - Poster presentation: Recommendations for diagnosis and treatment of Lyme borreliosis: guidelines and consensus papers from specialist societies and expert groups in Europe and North America. Lyme borreliosis guidelines - poster (PDF, 42 KB)
  • November 2009 - EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis. Mygland A, Ljøstad U, Fingerle V, Rupprecht T, Schmutzhard E, Steiner I. Eur J Neurol. 2010;17:8-16. This paper presents evidence-based recommendations for diagnosis and treatment of neuroborreliosis on behalf of the European federation of Neurological Societies.
  • August 2008Oral doxycycline versus intravenous ceftriaxone for European Lyme neuroborreliosis: a multicentre non-inferiority, double-blind randomised trial. Ljostad U, Skogvoll E, Eikellans E, Midgard R, Skarpaas T, Berg A, Mygland A. Lancet Neurology 2008;7:690-695.  This paper describes a randomised double-blind trial of treatments for Lyme neuroborreliosis in 118 patients in southern Norway, which demonstrated non-inferiority of oral doxycycline 200mg daily for 14 days compared to intravenous ceftriaxone 2g daily for 14 days.
  • June 2008Tick-borne diseases, Part 1: Lyme disease. Edlow J (Ed) Infect Dis Clin N Am 2008;22:195-376. An issue comprising 11 review articles on various aspects of the biology, clinical presentations, diagnosis and management of Lyme borreliosis, which comprehensively summarise current knowledge.
  • October 2007 - A critical appraisal of “chronic Lyme disease”. Feder HM, Johnson BJB, O’Connell S, Shapiro ED, Wormser GP, and the Ad-Hoc International Lyme disease study group. New Engl J Med 2007;357:1422-30.This article reviews the investigation, diagnosis and management of patients with longstanding infection, patients with continuing symptoms following treated Lyme disease and the misdiagnosis of “chronic Lyme disease” in patients who have other conditions. Available free at
  • May 2007 - Practice Parameter: Treatment of nervous system Lyme disease (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Halperin JJ, Shapiro ED, Logigian El et al. Neurology 2007;69:91-102. This evidence-based review by the Quality Standards Subcommittee of the American Academy of Neurology reports on efficacy of different treatment regimens for nervous system Lyme disease.Available free at  
  • October 2006. The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America. Wormser G P, Dattwyler R J, Shapiro E D, et al. Clinical Infectious Diseases 2006; 43: 1089-34.  New guidelines prepared by the Infectious Diseases Society of America for healthcare providers caring for patients with these infections or who may be at risk from them. Available at
  • December 2004. ESCMID STUDY GROUP REPORT: Guidelines for the diagnosis of tick-borne bacterial diseases in Europe. Brouqui P  et al. Members of ESCAR (ESCMID Study Group on Coxiella, Anaplasma, Rickettsia and Bartonella) and the European Network for Surveillance of Tick-Borne Diseases. Clinical Microbiology and Infection, 2004:10(12);1108-32. These guidelines aim to help clinicians and microbiologists in diagnosing infections, including Lyme disease, that are transmitted by tick bites. Available at
  • November 2003. Seminar: Lyme borreliosis. Stanek G, Strle F.Lancet 362:1639 -47


Other useful documents

  • 2006: A report on unorthodox and unvalidated laboratory tests in the diagnosis of Lyme borreliosis prepared by Professor Brian Duerden, Inspector of Microbiology and Infection Control, UK Department of Health. "Unorthodox and unvalidated laboratory tests in the diagnosis of Lyme borreliosis and in relation to medically unexplained symptoms". Department of Health, London, UK, 2006. Available from the Department of Health website [external link].
  • 2004: Tick Management Handbook (Warning: large file, 24MB). Available at

Last reviewed: 7 August 2013