Women in Science::

Florence Margaret Durham, 1869 - 1949

Florence Durham worked at NIMR in the Division of Biochemistry and Pharmacology

Florence DurhamFlorence Durham worked with William Bateson at Cambridge and applied his concept of epistasis to the inheritance of coat color in mice to explain the dominance relationships of a number of phenotypes. At NIMR (1919-1930) she was involved with establishing biological standards for neosalvarsan, an early treatment for syphilis, but she also conducted a nine-year investigation of the genetics of mice that suggested parental alcoholism (in the mouse) was not an inheritable trait.

Epistasis in mice ::

Epistasis in mice

The double recessive (cc) genotype suppresses B by epistasis so that white mice are over represented in the progeny.

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