The Investigation of Events that followed the death of Cyril Mark Isaacs



Main conclusions

Unanswered questions about the joint programme


Section 1  What happened after Mr Isaacs' death

Ch 1  The death of Cyril Mark Isaacs

Ch 2  Investigation of Mr Isaacs' death, the inquest and its aftermath

Ch 3  Investigation of the post mortem examination of Mr Isaacs at Prestwich mortuary

Ch 4  Were other organs of Mr Isaacs retained for use at Manchester University?

Section 2  Research on brains retained at post mortem

Ch 5  The legal framework: guidance to the NHS on organ retention and the collection of pituitary glands, and Home Office advice to Coroners

Ch 6  Ethics Committees and access to health records for post mortem research

Ch 7  The retention of brains after post mortem and the origins of brain research and brain banks

Ch 8  The Cerebral Function Unit and the Neuro Special Pathology Collection at Manchester University

Section 3  The research programme of the Departments of Physiology and Psychiatry of Manchester University (the 'Joint Programme')

Ch 9  Origin of the joint programme, funding application to the North West Regional Health Authority and progress 1985-1988

Ch 10  Brain collection at Prestwich mortuary 1985-1989 and arrangements with the Coroner's office

Ch 11   Development of the joint programme at Manchester   University from 1988: applications for research funds and awards

Ch 12  Prestwich mortuary. Application to the Salford Ethics Committee, January 1986

Ch 13   North Manchester General Hospital mortuary. Application to the North Manchester Ethics Committee

Ch 14   Action to enlarge the programme and increase the collection of brains from other hospitals: approaches to consultants and Ethics Committees

Ch 15  Warrington General Hospital. Application to Warrington Hospital Ethics Committee

Ch 16   Analysis of brains collected for the brain bank of the joint research programme 1985-1997

Ch 17  What happened to the brains obtained for the joint programme?

Ch 18  Approval of the joint programme by Ethics Committees and letters to general practitioners of 'control' cases

Ch 19  Pathology reports submitted to Coroners in Manchester and Cheshire

Ch 20  Access to medical records

Ch 21  Who was aware of the role of the North Manchester   Coroner's office in identifying suitable brains for the joint programme?

Ch 22   Was the retention of brains known to Coroners in Manchester and Cheshire?

Ch 23  Consent from relatives for brain retention

Ch 24  Other features of the joint programme  

Ch 25  Why were brains from Coroners' post mortems retained? Unanswered questions about the joint programme

Section 4  Research at other locations on brains from Coroners' cases

Ch 26  The Cambridge brain bank

Ch 27  The death of David Webb

Ch 28  Queen's Medical Centre, Nottingham

Ch 29  The death of Stuart Fayle

Ch 30  The Radcliffe Infirmary, Oxford

Ch 31  Brain collections used for research under Coroners Rules 9 and 12

Ch 32  Centres that carried out research under Coroners Rules 9 and 12

Ch 33  The Corsellis collection

Ch 34  Questionnaire to NHS Trusts

Ch 35  The importance of openness where brains from Coroners' cases are retained for diagnostic purposes

Section 5   The collection and use of brains for teaching

Ch 36  The retention of brains for teaching

Section 6  Brain retention and the Special Hospitals

Ch 37  Brain retention from post mortems after death in the Special Hospitals

Section 7  Research funding organisations and Royal Colleges

Ch 38  The Medical Research Council and post mortem brain banks for research

Ch 39  The Wellcome Trust: funding of brain research

Ch 40  The Royal College of Pathologists: guidance

Ch 41  The Royal College of Psychiatrists: guidance

Section 8  Approaches to post mortems and organ retention

Ch 42  Pathologists and post mortem reports

Ch 43  The different purposes of Coroners' and hospital post mortems

Ch 44  Legislation on the use of bodies, organs and tissues; Coroners' post mortems; procedures and alternatives

Ch 45  Views of relatives and religious faiths on post mortems and organ retention

Section 9   The importance of post mortem research to the future of Health Care

Ch 46  The benefits of post mortem research: clinical and ethical aspects of the retention of organs and tissues

Section 10   What has already changed and further changes that are needed

Ch 47  Changes to procedures of Coroners' post mortems to prevent unauthorised brain retention