Minocycline Hydrochloride (Minocycline 100mg modified-release capsules)



Information specific to: Minocycline 100mg modified-release capsules when used in Acne.

Your medicine

Minocycline hydrochloride is used to treat acne. It works by inhibiting the growth of certain types of bacteria that may cause acne.

Other information about Minocycline hydrochloride:

  • this medicine has to be taken for at least six weeks to treat acne. After this time your prescriber will review the need for you to have further treatment with Minocycline hydrochloride

Do not share your medicine with other people. It may not be suitable for them and may harm them.

The pharmacy label on your medicine tells you how much medicine you should take. It also tells you how often you should take your medicine. This is the dose that you and your prescriber have agreed you should take. You should not change the dose of your medicine unless you are told to do so by your prescriber.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

Whether this medicine is suitable for you

Minocycline hydrochloride is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

  • are allergic or sensitive to or have had a reaction to any of the ingredients in the medicine
  • have kidney problems
  • are pregnant
  • are breast-feeding
  • have myasthenia gravis
  • have liver problems
  • have lupus or a lupus-like problem
  • are elderly
  • are allergic or sensitive to or have had a bad reaction to tetracyclines or medicines similar to Minocycline hydrochloride

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for a child under the age of 12 years.

As part of the process of assessing suitability to take this medicine a prescriber may also arrange tests:

  • to check that this medicine is having the desired effect
  • to check that this medicine is not having any undesired effects

Over time it is possible that Minocycline hydrochloride can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Minocycline hydrochloride has become unsuitable, it is important that the prescriber is contacted immediately.


Alcohol can interact with certain medicines.

In the case of Minocycline hydrochloride:

  • this medicine may interact with alcohol

If you choose to drink alcohol while taking this medicine, it is best that you only drink alcohol in moderation. For more advice speak to your prescriber.


Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Minocycline hydrochloride:

  • there are no specific foods that you must exclude from your diet when taking Minocycline hydrochloride

Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

In the case of Minocycline hydrochloride:

  • this medicine could affect your ability to drive or operate machinery

You should see how this medicine affects you before you judge whether you are safe to drive or operate machinery. If you are in any doubt about whether you should drive or operate machinery, talk to your prescriber.

Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Minocycline hydrochloride:

  • this medicine may harm your baby if taken during pregnancy. If you become pregnant, or think you have become pregnant while taking Minocycline hydrochloride, you must contact your prescriber
  • this medicine may make oral contraceptive pills less effective. Seek medical advice if you are taking an oral contraceptive and bleed in between menstrual periods or have diarrhoea
  • you should only take this medicine during pregnancy if your doctor thinks that you need it

You need to discuss your specific circumstances with your doctor to weigh up the overall risks and benefits of taking this medicine. You and your doctor can make a decision about whether you are going to take this medicine during pregnancy.

If the decision is that you should not have Minocycline hydrochloride, then you should discuss whether there is an alternative medicine that you could take during pregnancy.


Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

In the case of Minocycline hydrochloride:

  • women who are breast-feeding must not take this medicine

Before you take Minocycline hydrochloride you should discuss breast-feeding with your doctor or midwife. They will help you decide what is best for you and your baby based on the benefits and risks associated with this medicine. If you wish to breast-feed you should discuss with your prescriber whether there are any other medicines you could take which would also allow you to breast-feed. You should not stop this medicine without taking advice from your doctor.

Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Minocycline hydrochloride:

  • isotretinoin
  • quinapril
  • penicillin
  • retinol

The following types of medicine may interact with Minocycline hydrochloride:

  • antacids
  • oral contraceptives
  • mineral salts
  • medicines that are damaging to the liver
  • diuretics
  • anticoagulants
  • preparations that contain bismuth
  • retinoids
  • ergot derivatives
  • ergot alkaloids

If you are taking Minocycline hydrochloride and one of the above medicines or types of medicines, make sure your prescriber knows about it.

Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins.

Make sure you tell your prescriber the names of all the complementary preparations and vitamins that you are taking or are planning to take.

Your prescriber can then decide whether it is appropriate for you to take combinations that are known to interact.

In the case of Minocycline hydrochloride:

  • this medicine may interact with preparations containing minerals such as calcium, zinc, aluminium, magnesium or iron. These preparations can affect the absorption of Minocycline hydrochloride and stop it from working as well as normal

If you have been prescribed Minocycline hydrochloride you should only take something on the above list on the specific advice of your prescriber or pharmacist.

Content provided by Datapharm

Patient information leaflets available for this medicine: