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Stem Cells Series

Tissue-engineered tracheal transplantation - Copyright: Elsevier An important potential application of human stem cells, through a more complete understanding of the genetic and molecular controls of cell division and differentiation, is the generation of cells and tissues that could be used for cell-based therapies. A two-part Series gives insight into the use of stem cells in the new discipline of regenerative medicine. In the first paper, the role of embryonic and adult-derived stem cells in cardiac repair is reviewed; the second paper discusses a novel approach for the replacement of complex tissues and whole organs involving the use of three-dimensional biological scaffolds made of allogeneic or xenogeneic extracellular matrix derived from non-autologous sources.
Selected Online First articles from The Lancet journals ahead of print publication.
Utako Okamoto - Copyright: Elsevier
Bringing women to the forefront of science and medicine
To mark International Women's Day, an Editorial recounts the inspirational story of Utako Okamoto who discovered the antifibrinolytic drug, tranexamic acid, in the 1950s.
Editorial The Lancet (online March 8)
Medical consultation - Copyright: Science Photo Library
Misoprostol and abortion
Meirik and colleagues analyse whether cervical preparation with misoprostol reduces complications of early surgical abortion compared with placebo.
Article The Lancet (online March 8)
First Nigerian paediatric living kidney transplant - Copyright: Science Photo Library
Center for Global Health (CGH)
The recently established Center for Global Health plans to build on the US Centers for Disease Control and Prevention's (CDC) 60-year history of evidence-based global health programmes.
Comment The Lancet (online March 7)
  • RCP should make an urgent statement against Health and Social Care Bill
    Correspondence The Lancet (online March 9)
  • Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study
    Article The Lancet Neurology (online March 9)
  • Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign (PREDICT): a prospective observational study
    Article The Lancet Neurology (online March 8)
  • Efficacy of immunoglobulin plus prednisoline for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial
    Article The Lancet (online March 8)
  • The global role of kidney transplantation
    Comment The Lancet (online March 8)
  • Conjugated equine oestrogen and breast cancer incidence and mortality in postmenopausal women with hysterectomy: extended follow-up of the Women's Health Initiative randomised placebo-controlled trial
    Article The Lancet Oncology (online March 7)
The Lancet's summary of news and developments across medicine
This Week in Medicine represents a snapshot of important, interesting, and sometimes quirky health-related happenings from around the world reported in the past week or so. This up-to-date content is free to all our users.
Making the most of evaluation

Papers published on The Lancet UK Policy Matters microsite raise concerns about the quality of past evaluations commissioned directly or indirectly by the Department of Health. Read the papers and accompanying blog post to find out more.

About UK Policy Matters

UK Policy Matters is a Lancet-based project which explores how UK policy changes affect health. On our microsite you will be able to access evidence-based summaries of different policies and tell us your experiences of how changes in policy have affected health.

How can you help?

If you have evidence of how policy has affected health or health care, we would like to hear from you. We are interested in all forms of evidence, including brief summaries of evidence from academics; and information from the public, managers, and healthcare workers about changes in services and their impact (individual experiences are welcomed).

See the Submit your evidence section of the site to share your experiences and submit your evidence.

Most read in The Lancet journals in January 2012
1. Eye can see a nest of worms!
Clinical Picture (2012) The Lancet Online First
2. Global health in 2012: development to sustainability
Editorial (2012) The Lancet 379 (9812), pp. 193
3. Health effects of financial crisis: omens of a Greek tragedy
Correspondence (2011) The Lancet 378 (9801), pp. 1457-1458
4. Anticoagulant loses its lustre
World Report (2012) The Lancet 379 (9813), pp. 301
5. The Research Works Act: a damaging threat to science
Editorial (2012) The Lancet 379 (9813), pp. 288
Most cited in The Lancet since 1996
1. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
Research (1998) Lancet 352 (9131), pp. 837-853
2. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: A randomised placebo-controlled trial
Research (2002) Lancet 360 (9326), pp. 7-22
3. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: Principal results of the Hypertension Optimal Treatment (HOT) randomised trial
Research (1998) Lancet 351 (9118), pp. 1755-1762
4. Peginterferon alfa-2b plus ribavirin compared with interferonalfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
Research (2001) Lancet 358 (9286), pp. 958-965
5. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
Research (1996) Lancet 348 (9038), pp. 1329-1339